منابع مشابه
Running on Ran Nuclear Transport and the Mitotic Spindle
sol and GTP hydrolysis. In particular, nuclear import Far from being passive participants in the process of is accomplished for proteins bearing classical nuclear mitosis, chromosomes have an active and essential role localization signals (NLS) by a heterodimeric receptor in the assembly of spindles required for their accurate comprised of a Ran-GTP binding protein, importin b, division into th...
متن کاملRAN Translation: Fragile X in the Running
In this issue of Neuron, Todd et al. (2013) reveal that noncanonical repeat associated non-AUG (RAN) translation occurs on nonexpanded (CGG)30-50 and premutation (CGG)59-160 repeats, associated with the FMR1 gene, suggesting that the polyglycine and polyalanine products might have natural and pathogenic roles.
متن کاملRan
How is Ran involved in nuclear transport? Cargo is transported through pores in the nuclear envelope, in association with carriers that bind to pore proteins called nucleoporins. A Ran–GTP gradient across the envelope is created by the asymmetric distribution of the GTPase activating protein known as RanGAP, which is in the cytosol, and of the guanine nucleotide exchange factor RanGEF in the nu...
متن کاملSmall GTPase Ran and Ran-binding proteins.
Abstract Like many other small GTPases, Ran functions in eukaryotic cells as a molecular switch that cycles between GTP- and GDP-bound forms. Through the proper modulation of the GTP/GDP cycle, Ran functions with a number of Ran-binding proteins to control a broad array of fundamental cellular functions, including nucleocytoplasmic transport, mitotic spindle assembly, and nuclear envelope and n...
متن کاملThe ran decathlon: multiple roles of Ran.
The Ran GTPase system affects many cellular processes, including the regulation of cell cycle progression, nuclear envelope structure and function, and nucleocytoplasmic transport. The biochemical basis for the involvement of Ran in nuclear import and export has been well documented, but the direct targets of Ran in other cellular processes have not yet been identified. There is, however, mount...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell
سال: 2001
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(01)00218-5